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. 2022 Mar 16;2022:6091671. doi: 10.1155/2022/6091671

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Copyright © 2022 Jiale Wang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Oral administration of JDYZF can reduce the deposition of Aβ and the expression of NLRP3 and GSDMD in the hippocampi of AD rats, which is consistent with the results of ELISA and Western blot. Use ImageJ software to measure the average optical density of Aβ in the hippocampal slices, and calculate the number of positive cells of NLRP3 and GSDMD in each field of view. The scale bar of Aβ is 200 um, the scale bar of NLRP3, and GSDMD is 100 um. Statistics and results display methods are the same as before.