Figure 8.

Representative electron micrographs of LV myocardial tissue from D2-mdx mice at 18 weeks. (a) An example from the D2-mdx Vehicle group that shows areas of randomly distributed mitochondria between poorly organised mitochondria, mitochondrial proliferation, and also some areas that are preserved (3000x mag). (b) Highly preserved regions with evenly sized and distributed mitochondria in the D2-mdx Debio-025+Perindopril group (4000x mag). (c) Examples of mitophagy and mitochondrial swelling in the D2-mdx Vehicle group (10,000x mag). (d) Examples of enlarged mitochondria with thick membranes and sparse cristae in the D2-mdx Debio-025 group (10,000x mag).