Table 7.

LV structural parameters in DBA/2 and D2-mdx mice at 10 and 18 weeks.

		DBA/2	D2-mdx
			Vehicle	Perindopril	Debio-025	Debio-025+Perindopril
LVEDd (mm)	10 weeks	3.7 ± 0.2	3.3 ± 0.3	3.4 ± 0.5	3.5 ± 0.3	3.3 ± 0.4
	18 weeks	3.5 ± 0.2	3.5 ± 0.5	3.6 ± 0.4	3.4 ± 0.4	3.7 ± 0.4
LVESd (mm)	10 weeks	2.3 ± 0.4	2.0 ± 0.4	2.0 ± 0.4	2.3 ± 0.4	2.1 ± 0.4
	18 weeks	1.9 ± 0.4	2.1 ± 0.5	2.4 ± 0.7	2.1 ± 0.3	2.6 ± 0.5
IVSd (diastole) (mm)	10 weeks	0.5 ± 0.1	0.6 ± 0.1	0.6 ± 0.1	0.6 ± 0.1	0.6 ± 0.1
	18 weeks	0.7 ± 0.1	0.7 ± 0.1	0.7 ± 0.2	0.8 ± 0.2	0.8 ± 0.2
IVSd (systole) (mm)	10 weeks	0.8 ± 0.2	1.0 ± 0.3	1.1 ± 0.1	0.9 ± 0.2	1.0 ± 0.2
	18 weeks	1.2 ± 0.1	1.2 ± 0.2	1.2 ± 0.2	1.2 ± 0.2	1.2 ± 0.2
PWT (diastole) (mm)	10 weeks	0.5 ± 0.1	0.7 ± 0.2	0.6 ± 0.1	0.6 ± 0.2	0.7 ± 0.1
	18 weeks	0.8 ± 0.2	0.8 ± 0.2	0.8 ± 0.1	0.7 ± 0.2	0.8 ± 0.2
PWT (systole) (mm)	10 weeks	1.0 ± 0.2	1.0 ± 0.3	0.9 ± 0.2	0.9 ± 0.2	0.9 ± 0.2
	18 weeks	1.1 ± 0.1	1.1 ± 0.3	1.2 ± 0.1	1.0 ± 0.2	1.0 ± 0.3
LV mass (mg)	10 weeks	59.0 ± 11.6	63.6 ± 13.9	63.3 ± 15.2	69.0 ± 21.4	67.2 ± 15.3
	18 weeks	82.4 ± 21.2	85.3 ± 20.6	90.2 ± 10.9	85.4 ± 25.4	100.1 ± 28.1