Table 8.
Vehicle | Perindopril | Debio-025 | Debio-025+Perindopril | |
---|---|---|---|---|
Bax | 2.23 ± 0.52 | 2.03 ± 0.47 | 2.56 ± 1.03 | 2.67 ± 0.63 |
Bcl-2 | 1.19 ± 0.26 | 1.34 ± 0.33 | 1.12 ± 0.30 | 1.18 ± 0.31 |
Bax/Bcl-2 | 1.95 ± 0.65 | 1.61 ± 0.54 | 2.33 ± 0.68 | 2.10 ± 0.75 |
Caspase-3 | 3.35 ± 1.58 | 3.0 ± 1.59 | 3.52 ± 0.97 | 4.10 ± 1.11 |
Beclin-1 | 3.37 ± 0.87 | 3.0 ± 0.54 | 3.10 ± 0.69 | 2.97 ± 0.79 |
MAO-A | 4.18 ± 0.54 | 4.36 ± 1.06 | 4.07 ± 0.90 | 4.18 ± 1.44 |
MAO-B | 7.09 ± 0.70 | 7.26 ± 0.76 | 6.65 ± 0.49 | 6.48 ± 0.51 |
NF-κB | 0.38 ± 0.19 | 0.44 ± 0.34 | 0.63 ± 0.62 | 0.63 ± 0.66 |
TNF-α | 1.16 ± 0.84 | 0.47 ± 0.54 | 3.07 ± 1.78 | 0.72 ± 0.61 |