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. 2022 Mar 16;2022:7346460. doi: 10.1155/2022/7346460

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Copyright © 2022 Bo Fan et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MMP2-AS1 contributes to proliferation, migration, and invasion of renal cell carcinoma cells by inducing MMP2 expression. (a–c) The CAKI-1 and 786-O cells were treated with MMP2-AS1 siRNA, or cotreated with miR-34c-5p inhibitor. (a) The cell viability was analyzed by CCK-8 assay. The cell proliferation was detected by colony formation assay. (c) The cell migration and invasion were tested by Transwell assay. (d, e) The expression of cyclin D1, cyclin E, E-cadherin, and vimentin was detected by Western blot. ^∗∗P < 0.01.