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. 2022 Mar 7;13:832589. doi: 10.3389/fphar.2022.832589

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Copyright © 2022 Jamaluddin, Chuang, Williams, Siow, Yang, Harris, Petersen, Bower, Chand, Brimble, Walker, Hay and Loomes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of antagonist with pre-incubation and a washout step on agonist concentration-response curves at human CGRP and AMY₁ receptors expressed in Cos-7 cells. (A) αCGRP_8-37, (B) αCGRP_7-37-palmitate, (C) V8C-palmitate, (D) K24C-palmitate, (E) K35C-palmitate. Solid and dashed lines indicate agonist concentration-response curves performed in the absence or presence of a washout step prior to agonist stimulation. Data points are plotted as a percentage of maximal CGRP-stimulated cAMP production and show mean ± SEM of five independent experiments.