TABLE 3.
pA2 values for αCGRP8-37 and lipidated αCGRP8-37 analogues at mCGRP and AMY1 receptors expressed in Cos-7 cells.
| αCGRP8-37 | αCGRP7-37-palmitate | V8C-palmitate | K24C-palmitate | K35C-palmitate | |
|---|---|---|---|---|---|
| mCGRPr | 9.00 ± 0.40 (5) | 9.89 ± 0.35 (5) | 9.70 ± 0.40 (4) a | 9.03 ± 1.00 (3) a | 7.56 ± 0.18 (4) a |
| mAMY1r | 7.61 ± 0.93 (3) a | 7.72 ± 0.28 (4) a | 7.61 ± 0.20 (5) | <6 (3) b | 6.78 ± 0.14 (3) a |
Comparisons to αCGRP8-37 were analyzed by one-way ANOVA followed by Dunnett’s multiple comparison test. Values are mean ± SEM (n).
a
Denotes that five experiments were conducted but only (n) repeats elicited measurable pA2 values.
b
Two repeats elicited pA2 values of 7.92 and 5.93.