Table 2.

Features of cryptococcal infections

Ref	Sx at Crypto Dg	Positive Bcx for Crypto	Diagnostic culture site	Organ/site affected	Co-infection	Anti-fungal Tx	Clinical outcome	Timing of death after Crypto Dg (D)
[9]	Fever, SOB	Yes	Bcx	Lung	MRSA	None	Dead	N/A
[10]	Fever, hypotension	No	Resp Cx	Lung	Leclercia adecarboxylata bacteremia	L-AmB,flu	Alive	N/A
[11]	Unsteady gait, aphasia	No	CSF Cx and CSF antigen	Meninges	None	L-AmB,flu	Alive	N/A
[12]	Septic shock	Yes	Bcx	Lung	Candidemia (Candida parapsilosis)	L-AmB,flu	Dead	D10
[13]	Agitation, somnolence	No	CSF Cx and CSF antigen (1:8192)	Meninges	None	L-AmB,flu	Alive	N/A
[14]	Septic shock	Yes	Bcx	Lung	None	None	Dead	N/A
[15]	Fever, respiratory insufficiency	No	Resp Cx	Lung	MDR Enterobacteriaceae	L-AmB then Isa	Dead	D17
[16]	Fever, encephalopathy	Yes	Bcx and CSF Cx	Meninges	None	L-AmB,flu	Worsening	N/A
[17]	Fever	Yes	Bcx, Serum cryptococcal antigen (titers 1/152), CSF Cx and cryptococcal antigen (1/1024)	Lung, meninges	None	L-Amb,Flu	Dead	D70
[18]	SOB	No	Resp Cx	Lung	Aspergillus fumigatus	L-Amb,Flu	Dead	D12
[19]	Confusion, fever	Yes	Bcx, CSF Cx and cryptococcal antigen (> 1/2560)	Meninges	No	L-Amb,Flu	Alive	N/A
[20]	Hypoxic	Yes	Bcx, CSF Cx and cryptococcal antigen (1/256)	Lung, meninges	No	L-Amb,Flu	Dead	D6
[21]	Fever	Yes	Bcx	Lung	No	L-Amb,	Alive	N/A

Bcx blood culture, Crypto cryptococcosis, CSF Cx cerebrospinal fluid culture, Dg diagnosis, D days, Flu flucytosine, L-AmB liposomal amphotericin B, MDR multi-drug resistant, MRSA methicillin resistant Staphylococcus aureus, Sx symptoms, SOB shortness of breath, Ref reference, Resp Cx respiratory culture, Tx treatment