Table 2.
Dose related changes in rat polychromatic erythrocytes and micronucleus frequency following administration of H. erinaceus β-glucan preparation to rats.
|
PCE% |
MN 0/00PCE |
||||
|---|---|---|---|---|---|
| 48 h | 72 h | 48 h | 72 h | ||
| Females | |||||
| Negative control | Sterile water | 3.44 ± 0.64 | 3.58 ± 0.58 | 0.18 ± 0.26 | 0.18 ± 0.66 |
| Positive control | Cyclophosphamide 80 mg/kg/day |
1.51 ± 0.52 | – | 21.00 ± 5.55* | – |
| H. erinaceus β-glucan | 500 mg/kg/day | 3.62 ± 0.55 | 3.72 ± 0.42 | 0.20 ± 0.27 | 0.40 ± 0.27 |
| 1000 mg/kg/day | 3.75 ± 0.72 | 3.82 ± 0.55 | 0.30 ± 0.45 | 0.30 ± 0.45 | |
| 2000 mg/kg/day | 3.45 ± 0.65 | 3.84 ± 0.66 | 0.30 ± 0.45 | 0.60 ± 0.45 | |
| Males | |||||
| Negative control | Sterile water | 3.62 ± 0.52 | 3.61 ± 0.36 | 0.64 ± 0.52 | 0.60 ± 0.45 |
| Positive control | Cyclophosphamide 80 mg/kg/day | 1.63 ± 0.45 | – | 21.50 ± 6.50* | – |
| H. erinaceus β-glucan | 500 mg/kg/day | 3.65 ± 0.75 | 3.72 ± 0.42 | 0.20 ± 0.27 | 0.30 ± 0.22 |
| 1000 mg/kg/day | 3.72 ± 0.60 | 3.45 ± 0.45 | 0.30 ± 0.45 | 0.20 ± 0.27 | |
| 2000 mg/kg/day | 3.65 ± 0.65 | 3.48 ± 0.33 | 0.20 ± 0.27 | 0.10 ± 0.22 | |
Values are mean ± SD for 12 (n = 12) rats in each group unless indicated.
* Poisson distribution, p < 0/05 indicated significant difference.