Table 3.
Dose (mg/kg/day) |
|||||
---|---|---|---|---|---|
Parameters | 0a | 500 | 1000 | 2000 | |
Males | |||||
Volume (mL) | 22.28 ± 7.02 | 19.85 ± 8.55 | 21.12 ± 9.09 | 20.63 ± 6.62 | |
Specific gravity | 1.02 ± 0.0044 | 1.02 ± 0.0045 | 1.02 ± 0.0045 | 1.02 ± 0.0048 | |
pH | 7.23 ± 0.55 | 7.31 ± 0.21 | 7.28 ± 0.33 | 7.26 ± 0.40 | |
Urobilinogen (EU/dL) | 0.39 ± 0.32 | 0.45 ± 0.35 | 0.46 ± 0.38 | 0.48 ± 0.37 | |
Females | |||||
Volume (mL) | 16.773 ± 8.39 | 13.52 ± 9.28 | 13.255 ± 9.62 | 14.52 ± 7.65 | |
Specific gravity | 1.02 ± 0.0045 | 1.02 ± 0.0048 | 1.02 ± 0.0045 | 1.02 ± 0.0050 | |
pH | 6.85 ± 0.44 | 6.92 ± 0.49 | 6.95 ± 0.18 | 6.73 ± 0.38 | |
Urobilinogen (EU/dL) | 0.34 ± 0.31 | 0.42 ± 0.31 | 0.37± 0.26 | 0.40 ± 0.36 |
aVehicle control: Sterile water for injection (WFI).
Values are mean ± SD for 12 rats in each group unless indicated.
*p < 0.05.