Table 4.
Effect of H. erinaceus β-glucan preparation on hematological parameters in male rats.
| Parameter | Units |
Dose (mg/kg/day) |
|||
|---|---|---|---|---|---|
| 0a | 500 | 1000 | 2000 | ||
| RBC | 106/μL | 9.532 ± 0.385 | 9.425 ± 0.384 | 9.505 ± 0.482 | 9.468 ± 0.338 |
| WBC | 103/μL | 8.715 ± 3.725 | 8.782 ± 3.246 | 8.425 ± 3.662 | 8.682 ± 3.017 |
| Neutrophil | % | 24.82 ± 7.15 | 26.15 ± 4.73 | 25.93 ± 6.75 | 26.22 ± 8.36 |
| Lymphocyte | % | 70.84 ± 7.80 | 69.12 ± 8.40 | 71.47 ± 9.38 | 70.15 ± 7.58 |
| Monocyte | % | 4.30 ± 1.25 | 4.15 ± 1.50 | 4.00 ± 1.45 | 4.24 ± 1.25 |
| Eosinophil | % | 0.28 ± 0.15 | 0.31 ± 0.10 | 0.42 ± 0.22* | 0.31 ± 0.17 |
| Basophil | % | 0.03 ± 0.04 | 0.03 ± 0.05 | 0.03 ± 0.02 | 0.0 3 ± 0.04 |
| MCV | fL | 47.27 ± 1.82 | 46.85 ± 1.67 | 47.23 ± 1.78 | 48.11 ± 1.58 |
| MCH | pg | 17.44 ± 0.60 | 17.50 ± 0.48 | 17.44 ± 0.56 | 17. 51 ± 0.48 |
| MCHC | g/dL | 38.88 ± 0.45 | 36.75 ± 0.78 | 38.56 ± 0.54 | 38.43 ± 0.68 |
| Platelet | 103/μL | 1285.3 ± 170.8 | 1301.5 ± 162.7 | 1294.8 ± 145.6 | 1283.9 ± 166.3 |
| Hemoglobin | g/dL | 16.34 ± 0.45 | 15.92 ± 0.58 | 16.36 ± 0.33 | 16.52 ± 0.86 |
| Hematocrit | % | 44.83 ± 1.84 | 46.75 ± 1.72 | 45.26 ± 2.27 | 45.13 ± 1.94 |
| APTT | Sec | 17.31 ± 0.99 | 17.19 ± 1.14 | 16.95 ± 0.88 | 16.92 ± 1.65 |
| Prothrombin time | Sec | 11.32 ± 1.82 | 11.51 ± 1.72 | 11.44 ± 1.66 | 11.38 ± 1.92 |
aVehicle control: Sterile water for injection (WFI).
Values are mean ± SD for 12 rats in each group.
*p < 0.05; in females there were no statically significant differences between the vehicle control and the test article treatment groups.
RBC = red blood cells; WBC = white blood cells; MCV = mean corpuscular volume; MCH = mean corpuscular hemoglobin; MCHC = mean corpuscular hemoglobin concentration; APTT = activated partial thromboplastin time.