Table 5.
Effect of H. erinaceu β-glucan preparation on hematological parameters in female rats.
| Parameter | Units |
Dose (mg/kg/day) |
|||
|---|---|---|---|---|---|
| 0a | 500 | 1000 | 2000 | ||
| RBC | 106/μL | 8.332 ± 0.354 | 8.427 ± 0.385 | 8.382 ± 0.328 | 8.395 ± 0.354 |
| WBC | 103/μL | 7.452 ± 2.862 | 7.345 ± 3.285 | 7.128 ± 2.873 | 7.622 ± 2.179 |
| Neutrophil | % | 18.85 ± 6.24 | 17.83 ± 7.28 | 18.15 ± 4.65 | 17.13 ± 8.06 |
| Lymphocyte | % | 80.38 ± 5.74 | 78.48 ± 8.71 | 77.44 ± 6.48 | 78.36 ± 7.85 |
| Monocyte | % | 4.04 ± 0.77 | 3.65 ± 0.87 | 3.92 ± 0.68 | 3.74 ± 0.77 |
| Eosinophil | % | 0.28 ± 0.14 | 0.26 ± 0.17 | 0.25 ± 0.18 | 0.26 ± 0.18 |
| Basophil | % | 0.03 ± 0.09 | 0.02 ± 0.04 | 0.01 ± 0.03 | 0.02 ± 0.04 |
| MCV | fL | 55.22 ± 1.11 | 54.77 ± 2.56 | 53.67 ± 2.83 | 54.84 ± 1.44 |
| MCH | pg | 18.60 ± 0.38 | 18.25 ± 0.49 | 18.35 ± 0.78 | 18.45 ± 0.35 |
| MCHC | g/dL | 34.64 ± 0.58 | 35.27 ± 0.68 | 35.79 ± 0.42 | 35.86 ± 0.75 |
| Platelet | 103/μL | 1090.3 ± 130.2 | 1092.2 ± 153.8 | 1084.6 ± 135.1 | 1102.2 ± 151.6 |
| Hemoglobin | g/dL | 15.48 ± 0.46 | 15.32 ± 0.51 | 15.42 ± 0.64 | 15.57 ± 0.68 |
| Hematocrit | % | 42.78 ± 1.56 | 43.12 ± 1.45 | 43.36 ± 1.64 | 43.75 ± 1.82 |
| APPT | Sec | 14.75 ± 1.27 | 14.67 ± 0.92 | 14.33 ± 0.90 | 14.65 ± 1.06 |
| Prothrombin time | Sec | 9.10 ± 0.24 | 9.14 ± 0.22 | 9.16 ± 0.25 | 9.08 ± 0.20 |
aVehicle control: Sterile water for injection (WFI).
n = 12.
Values are mean ± SD for 12 rats in each group unless indicated. There were no statically significant differences between the vehicle control and the test article treatment groups.
RBC = red blood cells; WBC = white blood cells; MCV = mean corpuscular volume; MCH = mean corpuscular hemoglobin; MCHC = mean corpuscular hemoglobin concentration; APTT = activated partial thromboplastin time.