Table 6.

Effect of H. erinaceus β-glucan preparation on serum chemistry parameters in male rats.

Parameter	Units	Dose (mg/kg/day)				Historical control data1
		0a	500	1000	2000
Glucose	mg/dL	170.35 ± 25.64	165.42 ± 24.38	163.25 ± 28.56	170.21 ± 24.74	–
Cholesterol	mg/dL	58.42 ± 15.20	60.03 ± 16.34	55.78 ± 14.02	59.62 ± 12.46	–
Triglyceride	mg/dL	28.46 ± 19.47	24.59 ± 14.32	26.13 ± 9.81	25.62 ± 11.37	–
Creatinine	mg/dL	0.44 ± 0.09	0.48 ± 0.05	0.44 ± 0.05	0.456 ± 0.08	–
AST	U/L	122.75 ± 44.29	114.70 ± 20.85	128.44 ± 20.28	130.87 ± 33.65	–
ALT	U/L	29.40 ± 2.53	28.57 ± 3.06	28.49 ± 4.02	31.42 ± 5.10	–
Total protein	g/dL	6.60 ± 0.16	6.55 ± 0.22	6.64 ± 0.39	6.77 ± 0.30	–
Total bilirubin	mg/dL	0.053 ± 0.005	0.060 ± 0.005	0.060 ± 0.006	0.056 ± 0.017	–
gamma-glutamyl transferase	U/L	NA	NA	NA	NA	–
Alkaline phosphatase	U/L	227.42 ± 35.25	230.24 ± 36.72	234.88 ± 35.36	238.07 ± 39.62	–
Amylase	U/L	1348.5 ± 175.4	1393.8 ± 165.6	1432.8 ± 225.3	1417.1 ± 200.3	–
Albumin	g/dL	4.03 ± 0.16	4.15 ± 0.22	4.09 ± 0.2	432 ± 0.152*	3.46 ∼ 4.49
Creatine kinase	U/L	715.52 ± 310.12	661.43 ± 249.18	695.89 ± 270.63	704.75 ± 300.55	–
Sodium	mmol/L	141.56 ± 1.05	144.50 ± 1.52	148.12 ± 1.76*	148.25 ± 1.47*	140.95 ∼ 148.99
Potassium	mmol/L	4.492 ± 0.245	4.483 ± 0.249	4.534 ± 0.167	4.510 ± 0.274	–
Phosphorus	mg/dL	6.84 ± 0.73	6.68 ± 0.86	6.75 ± 0.85	6.92 ± 0.52	–
Calcium	mg/dL	10.05 ± 0.35	10.12 ± 0.42	10.09 ± 0.67	10.17 ± 0.29	–
Chloride	mmol/L	104.32 ± 2.93	103.14 ± 2.17	110.62 ± 1.72*	102.12 ± 1.62	101.15 ∼ 114.43
BUN	mg/dL	14.81 ± 1.37	15.27 ± 1.52	14.49 ± 2.37	14.96 ± 1.56	–

^aVehicle control: Sterile water for injection (WFI).

NA = No data available (Due to below detection limit).

¹Historical control data: Level Biotechnology Inc., Preclinical Testing Center.

Values are mean ± SD for 12 rats.

*p < 0.05.

AST = aspartate aminotransferase; ALT = alanine aminotransferase; BUN = blood urea nitrogen.