Table 7.

Effect of H. erinaceus β-glucan preparation on serum chemistry parameters in female rats.

Parameter	Units	Dose (mg/kg/day)				Historical control data1
		0a	500	1000	2000
Glucose	mg/dL	156.00 ± 19.19	148.33 ± 26.93	144.48 ± 17.43	142.16 ± 22.08	–
Cholesterol	mg/dL	74.55 ± 19.71	69.45 ± 12.70	69.98 ± 9.87	68.88 ± 15.24	–
Triglyceride	mg/dL	23.82 ± 9.56	26.79 ± 9.68	24.49 ± 5.12	29.91 ± 19.65	–
Creatinine	mg/dL	0.53 ± 0.09	0.55 ± 0.06	0.51 ± 0.08	0.53 ± 0.09	–
AST	U/L	95.72 ± 14.46	89.34 ± 17.68	91.03 ± 15.30	98.37 ± 19.25	–
ALT	U/L	24.12 ± 14.29	25.35 ± 8.45	26.83 ± 10.40	27.34 ± 8.88	–
Total protein	g/dL	6.52 ± 0.42	6.45 ± 0.33	7.13 ± 0.26*	6.61 ± 0.18	5.72 ∼ 7.98
Total bilirubin	mg/dL	0.063 ± 0.015	0.063 ± 0.005	0.067 ± 0.006	0.076 ± 0.027	–
gamma-glutamyl transferase	U/L	NA	NA	NA	NA	–
Alkaline phosphatase	U/L	114.80 ± 34.33	125.16 ± 30.6*	118.77 ± 25.35	132.35 ± 38.18*	58.16 ∼ 176.63
Amylase	U/L	997.30 ± 156.20	1022.50 ± 178.40	1062.50 ± 160.30	1005.30 ± 170.50	–
Albumin	g/dL	4.65 ± 0.27	4.82 ± 0.37	4.92 ± 0.56	4.58 ± 0.37	–
Creatine kinase	U/L	389.50 ± 143.71	354.16 ± 128.63	351.93 ± 98.37	393.69 ± 163.03	–
Sodium	mmol/L	140.25 ± 1.65	148.15 ± 1.20*	147.20 ± 2.26*	142.18 ± 1.66	132.51 ∼ 151.47
Potassium	mmol/L	3.982 ± 0.318	3.945 ± 0.250	4.025 ± 0.332	4.106 ± 0.217	–
Phosphorus	mg/dL	5.84 ± 0.69	6.02 ± 0.77	5.82 ± 0.93	5.96 ± 0.65	–
Calcium	mg/dL	10.40 ± 0.35	10.45 ± 0.75	10.05 ± 0.64	10.36 ± 0.35	–
Chloride	mmol/L	105.66 ± 1.68	104.75 ± 1.33	105.22 ± 2.70	105.20 ± 1.80	–
BUN	mg/dL	15.90 ± 2.06	16.10 ± 1.63	16.60 ± 1.86	16.72 ± 1.70	–

^aVehicle control: Sterile water for injection (WFI).

NA = No data available (Due to below detection limit).

¹Historical control data: Level Biotechnology Inc., Preclinical Testing Center.

Values are mean ± SD for 12 rats in each group unless mentioned.

*p < 0.05.

AST = aspartate aminotransferase; ALT = alanine aminotransferase; BUN = blood urea nitrogen.