Fig. 3. Time-course dynamics of Omicron in vivo.
Syrian hamsters were intranasally inoculated with saline (n = 6, uninfected control), B.1.1 (n = 6), Delta (n = 6) or Omicron (n = 6). Six hamsters of the same age were mock-infected. Body weight (a), Penh (b), Rpef (c), SpO2 (d) and viral RNA load in oral swabs (e) were routinely measured. Data are mean ± s.e.m. In a–d, statistically significant differences versus B.1.1 and Delta through time points were determined by multiple regression. In e, statistically significant differences of the dynamics versus B.1.1 and Delta were determined by a permutation test. FWERs calculated using the Holm method are indicated.