Figure 11.

Paclitaxel treatment increased GFP signal among epidermal Langerhans cells (LCs). (A) Total epidermal LCs counts were increased among the paclitaxel-treated group compared with cremophor-vehicle treatment. (B) Location breakouts of the total GFP dermal dendritic cell and epidermal LCs populations. *P < 0.05 vs vehicle treatment; **P < 0.01 vehicle treatment vs corresponding paclitaxel treatment, unpaired 2 sample t test. Samples were derived from mice perfused 16 days after initiation of paclitaxel dosing as described in Methods. GFP, green fluorescent protein; LC, Langerhans cell.