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. 2021 Sep 24;163(5):834–851. doi: 10.1097/j.pain.0000000000002502

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Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 6. — Impact of paclitaxel and the CB₂ agonist AM1710 on cytokine and chemokine mRNA expression levels in the lumbar spinal cord from CB₂^EGFP mice. Acute intraplantar injection of AM1710 (30 µg i.pl.) increased the spinal mRNA levels of anti-inflammatory cytokine IL-10 and proinflammatory cytokine TNF-α and MCP-1. Data are expressed as mean ± SEM. (n = 6-7 mixed sex/group). * P < 0.05 vs vehicle in lieu of AM1710, unpaired sample 2 tailed t test. EGFP, enhanced green fluorescent protein; IL-10, interleukin-10; MCP-1, monocyte chemoattractant protein-1; TNF-tumor necrosis factor alpha.