Table 5.

Neurocognitive impairment results in randomized clinical trial on the effect of CPAP in exclusively elderly series

Study (RCT)	n	Age	CPAP vs no-CPAP
			Digit Span	Digit Symbol test	HADS depression	HADS anxiety	TMT-A	TMT-B
Aloia et al(145)	12	64.8 ± 4.7	-	5.74 (C95%, 1.69 - 9.79), p<0.001	-	-	-	1.8–48.0 (6.8 <0.05
Dalmases et al(142)	33	71.3 ± 5.5	0.79 (CI95%,−0.30, 1.88), N.S	5.74 (CI95%,1.69, 9.79), p<0.01	−0.42 (CI95%:−1.84, 0.99), N.S	−0.43 (CI95%:−1.0, −1.88), N.S	−2.68 (CI95%:−16, 10.6), N.S	−47.64 (CI95%:−81.8, −13.4), p<0.01
Mc Millan et al(140)	278	71.1	-	1.1 (CI95%,−0.6, 2.7) N.S.	−0.4 (CI95%: −1.0, 0.3); N.S	−0.2 (CI95%: −0.9, 0.5); N.S	-	6.2 (CI95% −3.4, 15.8); N.S
Martinez-Garcia et al(139)	224	75.5 ± 3.9	−0.08 (CI95%, −0.55, 0.4; N.S	−1.43 (CI95%, −2.84, −0.02); p<0.05.	1.98 (CI95%: 1.18-2.7), p<0.001	1.19 (CI95% 0.22-2.16); p=0.016	10 (−4–34) versus 0 (−16–11); p=0.029)	−9.4 (95% CI −24–5.3) N.S
Ponce et al(141)	145	74.9 ± 4.6	−0.2 (CI95%, −0.6, 0.9); NS	−0.9 (CI95%, −2.5, −4.3) N.S	0.2 (CI95%, −0.9, −0.5), N.S	0.8 (CI95%, 0.2–1.7), N.S	−5.6 (CI95%, −14.3–3), N.S	−9.4 (95% CI −24–5.3). p<0.05
Richards et al(146)	54	70.1 ± 8.3	-	1.68 (CI95%:0.73-2.62), p<0.05	-	-	-	-

HADS: Hospital Anxiety and Depression Scale; TMT: Trail making Test; CPAP: Continuous positive airway pressure, CI: Confidence interval; RCT: Randomized controlled trail.