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. 2022 Jan 8;30(1):43–57. doi: 10.1007/s10577-021-09678-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Mobility of kinetochore proteins in living cells. Schematic summary of FRAP analyses in this study. CENP-C is mobile in interphase but becomes immobile during mitosis (left two illustrations). In cells expressing CENP-C mutants lacking CENP-A binding, CENP-C is more mobile than wild-type CENP-C during mitosis; however, the mobilities of mutant CENP-C and wild-type CENP-C are comparable in interphase cells. In contrast to CENP-C, CENP-T and CENP-H are immobilized during both interphase and mitosis. CENP-T remains immobilized in mitotic cells expressing the CENP-C mutant lacking the CENP-A nucleosome-binding region (right two illustrations). Dsn1 mobility during mitosis depends on the mobility of CENP-C