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. 2022 Mar 23;12:4933. doi: 10.1038/s41598-022-08867-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) The overall survival time of ten hub genes. In Kaplan–Meier plots, red lines indicate patients with lower hub gene expression, whereas green lines indicate greater hub gene expression. (B) The figure demonstrates a schematic illustration of the DECs-FImiRNAs-FImRNA regulatory network for five final hub genes located inside the cytoplasm. The upregulation of two DECs causes the downregulation of three miRNAs, limiting miRNA-mediated hub gene degradation, and HCC may develop due to hepatic overexpression of these five hub genes.