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. 2022 Mar 23;13(3):260. doi: 10.1038/s41419-022-04690-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Heat maps of the expression levels of DEGs from GEO showed significant differential expression between breast cancer (BC) and normal tissues. B KEGG pathway map of the DEGs. C The upregulated DEGs obtained from GEO were verified by the TCGA database. D The downregulated DEGs obtained from GEO were verified by the TCGA database. E Protein-protein interaction (PPI) network constructed with the DEGs. Node size was proportional to its degree. Red nodes represented upregulated genes, and blue nodes represent downregulated genes. F The sequence of the top 30 genes with the highest degrees. Error bars indicated SEM. **p < 0.01.