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. 2022 Mar 23;13(3):260. doi: 10.1038/s41419-022-04690-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — MCF-7 and MDA-MB-231 cells were transfected with LV-GNG2 or LV-GFP as described in the Methods. A GNG2 overexpression in MCF-7 cells increased glycogen contents, Scale bars, 50 μm. B Total and phosphorylated Akt, ERK, and GSK3β in MCF-7 and MDA-MB-231 cells. C–F Enrichment plots from gene set enrichment analysis (GSEA). GSEA analyses showing differential enrichment of genes related to oxidative phosphorylation and biosynthesis of unsaturated fatty acids (C), spliceosome and base excision repair (D), DNA replication and apoptosis (E), cytotoxicity mediated by natural killer cell and antigen processing and presentation (F) in GNG2-related BC. NES normalized enrichment score.