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. 2022 Feb 5;27(2):149–164. doi: 10.1007/s12192-022-01257-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The effects of diabetes and myocardial IRI on ferroptosis and NRF2 pathway. A Basic characteristics of diabetic rats. Water intake and food consumption were the average value of 8 weeks. Body weight and plasma glucose were recorded before inducing myocardial ischemia–reperfusion. B Intraperitoneal glucose tolerance test and oral glucose tolerance test of diabetic rats. C Representative M-mode images by echocardiography. D Infarct size was detected by TTC. E The levels of CK-MB and LDH in serum were detected. F Histopathological changes of myocardium were detected by HE staining. G The protein levels of NRF2, FPN1, ACSL4, and GPX4 in myocardial tissue were detected by western blot. H The mRNA levels of NRF2, ACSL4, and GPX4 in myocardial tissue were detected by qRT-PCR. The results are expressed as the means ± SD. N = 8 for each group. ^**P < 0.05 vs. NS group. ^##P < 0.05 vs. NIR group. ^&&P < 0.05 vs. DS group. IPGTT intraperitoneal glucose tolerance test, OGTT oral glucose tolerance test