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. 2022 Mar 23;12:4960. doi: 10.1038/s41598-022-09055-6

Table 3.

Comparison of VAS scores within groups and between groups at the end of the study [Mann–Whitney U test was used for testing each two groups. There were no significant differences between each two groups, except between low gluten and high gluten diet for abdominal pain (p = 0.002), and mid gluten and high gluten diet for impact on community function (p = 0.003)].

Group A Group B Group C p-value
Low-gluten (n = 7) Mid-gluten (n = 9) High-gluten (n = 9) GFD (n = 15) GCD (n = 10)
Baseline End p-value* Baseline End p-value* Baseline End p-value* Baseline End p-value* Baseline End p-value*
Pain (severity)
4 ± 2.9 5.4 ± 2.8 0.11 4.1 ± 3.5 3.3 ± 2.9 0.28 2.4 ± 2.1 1 ± 1.1 0.14 2.9 ± 2.8 2 ± 2.2 0.02 1.1 ± 1.6 1.9 ± 2.3 0.13 0.02
Pain (frequency)
4.6 ± 4.2 7 ± 3.7 0.10 1.3 ± 1.5 1.3 ± 1.5 1 0.7 ± 0.5 1 ± 1.4 0.68 1.9 ± 2.4 2.3 ± 3.3 0.54 0.7 ± 1.1 2 ± 2.8 0.07 0.048
Bloating
3.1 ± 2.9 3.6 ± 2.6 0.92 4.4 ± 1.9 4.1 ± 1.5 0.49 2.7 ± 2.1 2 ± 2.2 0.35 3.5 ± 2.6 2.5 ± 2.1 0.03 2.3 ± 2.8 3.5 ± 3.9 0.12 0.35
Satiety
2.3 ± 1.9 4.1 ± 2.5 0.12 2.4 ± 1.6 2.7 ± 1.2 0.67 1.7 ± 1.7 1.9 ± 2 0.71 3.6 ± 2.2 3.1 ± 1.9 0.08 2.3 ± 1 3.8 ± 3.1 0.04 0.20
Impact on community function
3.4 ± 2.6 4.3 ± 2.8 0.34 4.8 ± 2.1 5.1 ± 1.5 0.52 2.9 ± 2 2.1 ± 1.6 0.39 3.6 ± 2.6 2.7 ± 2 0.07 2 ± 1.6 3 ± 2.3 0.06 0.02
Defecation (times/day)
1 ± 1 0.9 ± 0.7 0.71 1.3 ± 0.5 1 ± 0.5 0.26 1.6 ± 1 2 ± 1.1 0.19 1.8 ± 1.9 1.4 ± 0.7 0.74 1.3 ± 1.1 1.3 ± 0.8 1 0.87
Defecation (type)
3.6 ± 1.6 3.4 ± 1.6 0.32 3.8 ± 1.2 4.2 ± 0.7 0.4 4 ± 0 4.4 ± 0.9 0.16 3.9 ± 0.7 3.8 ± 0.8 0.68 4.1 ± 0.7 3.9 ± 0.9 0.59 0.15
Total score
47.1 ± 19.8 54.3 ± 16.2 0.27 51.1 ± 11.9 51.1 ± 15.6 0.75 45.6 ± 15.9 27.8 ± 12.8 0.05 44.3 ± 22.6 37.7 ± 18.9 0.06 38 ± 20 42.5 ± 21.8 0.29 0.054

*p-value for comparison within each group using the Wilcoxon-signed rank test.

p-value for between-groups comparison using the Kruskal–Wallis test.