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. 2022 Mar 23;13:1571. doi: 10.1038/s41467-022-28986-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Voxel-wise analysis relating NvR LC-FC and longitudinal PACC5 measurements: lower NvR FC between the LC and the left hippocampus is associated with decline on the PACC5. Inference was performed using mixed-effects models including PACC5 as outcome variable, NvR LC-FC contrast estimates, time, their interactions, age, sex and years of education as fixed effects, random intercepts for participants and slopes for time (number of years between baseline and follow-up cognitive assessments). The FC maps were corrected for multiple comparisons using cluster-extent-based thresholding (number of participants n = 128 and number of observations is 753; cluster defining threshold Z > 3.1, two-tailed p < 0.05, FWER-corrected). Abbreviation: HIPP hippocampus.