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. 2022 Mar 23;13:1560. doi: 10.1038/s41467-022-29238-z

Table 2.

Pathway reconstruction and gap-filling of the staurosporine biosynthesis pathway with ATLASx.

Step KEGG ID EC number BNICE.ch rule Top BridgIT hit EC (KEGG ID, score) Reconstruction within ATLASx
1 R11119 1.4.3.- 1.4.3.- 1.4.3.23 (R09560, 0.95) Biotransformation with LCSB ID 2600177067
2 R11120 2-step reaction (spontaneous + 1.21.98.2) in bioDBa
3 R11121 1.13.12.- Not reconstructed by any suite of reaction rules
4 R11122 2.4.-.- 3-step reaction in chemATLASb
5 R11123 2-step reaction in bioATLASc
6 R11129 2.1.1.- 2.1.2.5 (R03189, 0.34) Biotransformation with LCSB ID 2600423725
7 R05757 2.1.1.13964 2.1.1.- 2.1.1.139 (R05757, 1.00) Biotransformation with LCSB ID 2600261843

a https://lcsb-databases.epfl.ch/Graph2/loadPathway/1/1468050408,1469435049,1468050416/2806125367,2806150968/0.

b https://lcsb-databases.epfl.ch/Graph2/loadPathway/1/1468050425,1469288899,277921848,1468050433/2603459454,2603467379,2682146339/0.

c https://lcsb-databases.epfl.ch/Graph2/loadPathway/1/1468050433,1469288674,1468050440/2603455158,2682148818/0.