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. 2022 Mar 23;12:4943. doi: 10.1038/s41598-022-08946-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of DGAT1 inhibition on lipid production from exogenous 2-MG and oleic acid. HepG2 cells were pre-incubated with or without the DGAT1 inhibitor (5 µM) or the DGAT1, MGAT2 (25 µM) and MGAT3 (50 µM) inhibitors together. After 1 h, 5 µCi [³H]OA, cold OA (0.25 mM final concentration) and 2-MG (0.2 mM final concentration) were added to the culture media and cells were incubated for a further 5 h. The incorporation of radioactivity into TG and DG in cells was then determined. Values for DMSO-treated controls: DG (22.3 × 10³ dpm/mg cell protein), TG (421 × 10³ dpm/mg cell protein). *p < 0.001 versus DMSO-treated cells; **p < 0.001 DGAT1 inhibitor versus DGAT1, MGAT2 and MGAT3 inhibitors together.