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. 2022 Mar 14;9:445–469. doi: 10.1016/j.toxrep.2022.03.011

Table 1.

List of flavonoids with anti-Alzheimer effect and their mechanism of action.

Flavonoids Mechanism of action References
Hesperidin Promotes neural differentiation [7]
Decrease β amyloid plaques
Inhibit AChE
Anthocyanin Decrease β amyloid protein Vepsalane et al., 2013
Nariginin Suppress neuronal death Hernandez-Mantes et al., 2006
Silibinin Suppress inflammatory response [246]
Decrease in ROS production
Quercetin Suppress apoptosis Lee et al., 2003
Increase AMPK activity
Down regulation of tau phosphorylation
Baicalein Increase dopaminergic level [105]
[281]
Resveratrol Increase BDNF production [298]
Inhibit AChE
Luteolin Decrease Aβ plaque formation Rezai-zadeh et al., 2009
Genistein Increase neural survival Weinreb et al., 2009
Decrease apoptosis
Decrease Aβ plaque formation
Myrecetin Inhibit butylcholinesterase activity Leclerc et al., 2001