Table 6.

List of flavonoids with hepatoprotective effect and their mechanism of action.

Flavonoids	Mechanism of action	References
Apigenin	Inhibit Nrf2-signaling	Tsaroucha et al., 2016
	Activate BCL-2 apoptotic pathway
Catechin	Modulate the expression of hepatic carcinoma factor	Yang et al., 2017
	Increase expressions of vital antioxidative signals
Curcumin	Suppress cytokines, lipid peroxidation, hepatic stellate cells, and Akt activation.	Nabavi et al., 2014
	Induce expression of Nrf2, SOD, CAT, and GSH.
Epicatechin	Downregulate liver enzymes	Shanmugam et al., 2017
Wogonoside	Increase oxidation process.	Wang et al., 2015
Resveratrol	Regulation lipogenesis.	[297]
	Reduce transcriptional factors, liver enzymesand cytokines.
Naringenin	Upregulate Nrf2 pathways	Esmaeili and Alilou, 2014
	Increase CAT, SOD
	Decrease AST, ALT, AP, GGT
Morin	Suppress NF-Kβ signaling	Caselli et al., 2016
Hyperoside	Regulate detoxifying enzymes phase II	Xie et al., 2016
	Activate Nrf2 signaling pathway	Zou et al., 2017