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. 2022 Mar 14;9:445–469. doi: 10.1016/j.toxrep.2022.03.011

Table 7.

List of flavonoids with antihypertensive effect and their mechanism of action.

Flavonoids Mechanism of action References
Epicatechin Antioxidant, reduce ROS and NO [131]
Vasodilatation
Kaempferol VSMC relaxation, vasodilatation [162]
Vascular Ca channel [94]
Quercetin Hyperpolarization, VSMC relaxation, vasodilatation [236]
Naringenin VSMC relaxation, vasodilatation [235]
Vascular BKca channel [162]
Daidzein Inhibit NADPH oxidase, antioxidant, reduce NO Vasodilatation [200]
Hesperetin Prevent endothelial dysfunction [196]
Inhibit atherosclerotic plaque development [252]
Increase NO generation [155], [156]
Reduce [Ca2 + ] [248]