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. 2022 Mar 14;9:445–469. doi: 10.1016/j.toxrep.2022.03.011

Table 8.

List of flavonoids cardioprotective effect and their mechanism of action.

Flavonoids Mechanism of action References
Cyanidin Increase eNOS Xu et al., 2007
Increase Thioredoxin
Quercetin Increase eNOS activity Shen et al., 2012
Increase Phosphorylation of eNOS
Decrease HOCl‐induced endothelial dysfunction
Proanthocyanidin Increase NO production Qian et al., 2017
Resveratrol Increase eNOS
Cyanidin‐3–glucoside Increase eNOS Edwards, et al., 2015
Luteolin Enhance relative coronary flow [24]
Induce vasorelaxion [117]
Reducing oxidative stress [31]
Prevent ischemia-reperfusion injury
Regulate potassium and calcium channels