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. 2022 Mar 17;21:15347354221086900. doi: 10.1177/15347354221086900

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — The inhibitory effect of hesperetin on the expression of RhoA and the activation of Rho-kinase in MDA-MB-231 breast cancer cells. (A) The expression of RhoA and ROCK activation (proportion of MYPT1 phosphorylation at T853 site to total MYPT1) in MDA-MB-231 cells were analyzed by western blot. (B and C) Quantification of experiments as in (A). The results showed that TGF-β1-induced increased expression of RhoA and p-MYPT1 were significantly blocked by hesperetin (50 and 100 μM). Data are expressed as the mean ± SD, n = 6. *P < 0.05 versus control group; # P < 0.05 versus TGF-β1 group.