Table 1.
Laboratory findings.
| Variable | Reference range | Day 1 | Day 3 | Day 6 | Day 8 | Day 10 and TCZ administration | Day 13 | Day 20 | Day 25 | Day 27 |
|---|---|---|---|---|---|---|---|---|---|---|
| White blood cells (/µL) | 4000–10,000 | 6520 | 13,648 | 9830 | 6409 | 4795 | 7529 | 7920 | 5098 | 5783 |
| Segmented neutrophils (/µL) | 1500–7000 | 3578 | 9007 | 7630 | 5900 | 4830 | 5690 | 5390 | 4970 | 4850 |
| Lymphocytes (/µL) | 1000–4000 | 100 | 201 | 320 | 350 | 290 | 590 | 870 | 740 | 780 |
| Hemoglobin (g/dL) | 12–16 | 12.4 | 11.5 | 12.9 | 11.4 | 11.1 | 12.8 | 12.2 | 11.3 | 11.5 |
| Platelets (×104/µL) | 15–40 | 9 | 11.3 | 12.3 | 11.4 | 10.9 | 8.5 | 5.4 | 7.8 | 10.3 |
| ALT (IU/L) | 0–55 | 76 | 69 | 93 | 78 | 63 | 54 | 61 | 55 | 72 |
| AST (IU/L) | 5–34 | 27 | 37 | 30 | 32 | 29 | 56 | 42 | 30 | 32 |
| LDH (IU/L) | 125–143 | 656 | 783 | 876 | 890 | 994 | 703 | 378 | 208 | 196 |
| IL-6 (pg/mL) | 0–7 | – | – | 217 | 255 | 262 | 26 | – | – | – |
| Serum ferritin (µg/L) | 20–300 | 560 | 654 | 876 | 987 | 1128 | 659 | 479 | 483 | 380 |
| Hematocrit (%) | 37–49 | 40 | 38 | 42 | 39 | 48 | 51 | 43 | 47 | 38 |
| Glucose (G/L) | 0.7–1.15 | 0.8 | 1.1 | 1.2 | 0.85 | 0.9 | 1 | 0.73 | 0.92 | 0.9 |
| CRP (mg/L) | 0–6 | 257 | 303 | 376 | 389 | 394 | 340 | 76 | 104 | 98 |
| Procalcitonin (ng/mL) | 0.0–0.05 | 0.01 | 0.3 | 0.07 | 0.03 | 0.02 | 0.02 | 0.01 | 0.03 | 0.03 |
| Total protein (g/L) | 64–83 | 76 | 70 | 64 | 68 | 69 | 65 | 69 | 72 | 69 |
| Albumin (mg/L) | 35–50 | 38 | 37 | 35 | 41 | 40.3 | 46 | 42 | 40 | 39 |
| High-sensitivity cardiac troponin (pg/mL) | 0–26 | 3 | 5 | 1.9 | 13 | 19 | 10 | 9 | 4 | 3 |
| Prothrombin time (seconds) | 11–13 | 11 | 11.8 | 11.9 | 12 | 12.1 | 11.9 | 11.8 | 11.6 | 11.7 |
| D-dimer (mg/L) | 0.0–0.5 | 3.6 | 4.3 | 4.9 | 5.8 | 6.4 | 5.3 | 4.7 | 3.2 | 2.1 |
| Fibrinogen (G/L) | 2–4 | 6.3 | 7.2 | 7.8 | 8.9 | 9.1 | 7.3 | 5.6 | 4.5 | 3.9 |
| Partial thromboplastin time (seconds) | 30–50 | 44 | 43 | 49 | 53 | 57 | 52 | 43 | 42 | 49 |
| Urea (mmol/L) | 2.5–7.6 | 3.65 | 4.76 | 4.38 | 3.98 | 5.67 | 4.98 | 5.68 | 4.98 | 3.87 |
| Creatinine (mg/L) | 6–12 | 8.3 | 9.7 | 10.1 | 10.3 | 8.8 | 8.4 | 7.9 | 9.1 | 10.2 |
ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDH, lactate dehydrogenase; CRP, C-reactive protein; TCZ, tocilizumab; IL-6, interleukin 6.