Table 1.
Introduction of the correlation between PPM1A and various diseases and the substrates involved.
| Associated diseases | Substrates of PPM1A | Correlation between PPM1A and disease | |
|---|---|---|---|
| Nephropathy | Fibrotic kidney38 | TGF-β1/Smad2/3 | ↓ |
| Diabetes/obesity | Diabetes44 | PSer273 | ↓ |
| Infection with vesicular stomatitis virus46 | TBK1/IKKε MAV | ↑ | |
| Infectious diseases | Mycobacterium tuberculosis20 | JNK | ↑ |
| HIV infection27 | CDK9 | ↑ | |
| Bladder cancer49 | TGF-β1/Smad2/3 | ↓ | |
| Renal cell carcinoma50 | TGF-β1/Smad2/3 | ↓ | |
| Cancer | Triple negative breast cancer51 | CDK | ↓ |
| Hepatocellular carcinoma52–54 | PXR Smad2/3 | ↓ | |
| Pancreatic duct cancer55 | – | ↓ | |
| Autoimmune disease | Ankylosing spondylitis56 | – | ↑ |
| Neurodegenerative diseases | Alzheimer's disease58 | – | – |
| Amyotrophic lateral sclerosis59 | – | – | |
| Huntington’s disease63 | HTT Ser-421 | ↑ | |
| Parkinson's disease64–68 | – | – |
Note: In Table 1, the references corresponding to related diseases have been explained. In the column of correlation, “↑” represents positive correlation, “↓” represents negative correlation, and “−” represents unknown or unclear.