TABLE 2.
CFU counts in organ homogenates from mice treated with 12- or 18-week courses of preventive therapy
| Preventive therapy regimen | Log10 CFU count
|
|
|---|---|---|
| Spleen | Lung | |
| 12-wk course | ||
| Placebo twice weekly | 3.86 ± 1.84 | 5.56 ± 1.36 |
| INH (25 mg/kg) daily | 2.37 ± 2.01 | 3.56 ± 2.10 |
| RIF (10 mg/kg) twice weekly | 4.26 ± 0.62 | 5.18 ± 0.69 |
| RPT (10 mg/kg) twice weekly | 3.49 ± 0.96 | 4.91 ± 0.73 |
| 18-wk course | ||
| Placebo, twice weekly | 3.24 ± 2.20 | 5.77 ± 0.11 |
| INH (25 mg/kg) daily | 1.93 ± 2.11 | 0.71 ± 1.34a |
| RIF (10 mg/kg) twice weekly | 4.11 ± 0.40 | 5.39 ± 0.49 |
| RPT (10 mg/kg) once weekly | 3.63 ± 1.18 | 4.67 ± 2.35 |
| RPT (10 mg/kg) once fortnightly | 2.13 ± 2.15 | 2.86 ± 3.14 |
| INH + RPT once weekly | 1.46 ± 2.04b | 1.78 ± 2.49ab |
a
Significantly lower than the placebo group (P < 0.005).
b
Significantly lower than the group of mice treated with RPT once weekly (P < 0.05).