Fig. 1.

A schematic pathway of inflammatory biomarkers regulated by catechins and their derivates in cell. TNFR1 TNF-α receptor 1, TLRs toll-like receptors, JAK2 Janus kinase 2, IRAK-4 IL-1 receptor-associated kinase-4, STAT1 Signal transducer and activator of transcription 1, IκB-α nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha, NF-κB nuclear factor kappa-light-chain-enhancer of activated B cells, IKK IκB kinase, MAPK mitogen-activated protein kinase, JNK c-Jun N-terminal kinases, ERK extracellular signal-regulated kinase, AP-1 activator protein 1, Akt protein kinase B, BAX BCL2 Associated X, ROS reactive oxygen species, Cas9 caspase-9, Cas3 caspase-3, iNOS inducible nitric oxide synthase, COX-2 cyclooxygenase-2, TNF-α tumor necrosis factor-α, IL-1β interleukin-1β, IL-8 interleukin-8, SOD superoxide dismutase, HO-1 heme oxygenase-1, NQO1 NAD(P)H quinone oxidoreductase 1, GPx glutathione peroxidase