Table 3.
Physiological studies of catechins on hepatic disease
| Materials | Dosesa | Species/organ (origin) | Stressorsb | Biomarkersc | References |
|---|---|---|---|---|---|
| EGCG | 6 g/kg/day | Wistar rats/liver | Ethanol |
↑Glycogen, ADH, ALDH, GST ↓AST, ALT, GGT, LDH, cytochrome P450, bilirubin |
Anuradha and Kaviarasan (2007) |
| Epicatechins | 300 mg/kg (p.o.) | Sprague Dawley rats/liver | CCl4 | ↓α‐SMA, TGF-β, p-ERK1/2, p-Smad1, TNF-α, MMP2, MMP9, IL-17 | Wang et al. (2018) |
| ( +)-Catechin | 16 μg/mL/well | Huh-7 cells/human hepatoma cells | HCV | ↓COX-2, p-NF-κB, NS5A-Myc | Lee et al. (2011) |
| Green tea catechin | 0.1% (w/v) (p.o.) | Sprague Dawley rats/Liver | BDL | ↓ALT, procollagen-α1(I), AP-1, α-SMA, 4-HNE, TGF-β1, TNF-α | Zhong et al. (2003) |
| Green tea catechin | 50 mg/kg/day (p.o.) | Wistar rats/liver | Sanfenon | ↓AST, ALT, 4-HNE, 8-OHdG, AP-1, TGF-β1, α‐SMA | Kobayashi et al. (2010) |
| Green tea catechin | 10% (w/v) (p.o.) | Hamsters/liver | CCl4 |
↑GSH, ADH, cytochrome P450 reductase, HDLC ↓MDA, total cholesterol, triglyceride, LDLC. p53 |
Elgawish et al. (2015) |
| Black tea catechin | 2% (w/v) (p.o.) | Sprague Dawley rats/liver | Aflatoxin |
↑SOD, catalase, GST, GR, GPx ↓AST, ALT, ALP |
Alm-Eldeen et al. (2015) |
aMaximal dose of referred study. Body weight (b.w.)
bAbbreviation of stressors. CCl4 carbon tetrachloride, HCV hepatitis C virus, BDL bile duct ligation
cAbbreviation of biomarkers. ADH alcohol dehydrogenase, ALDH aldehyde dehydrogenase, GST glutathione S-transferase, ALT alanine aminotransferase, AST aspartate aminotransferase, GGT gamma glutamyl peptidase, LDH lactate dehydrogenase, α‐SMA α-smooth muscle actin, TGF-β transforming growth factor-β, p-ERK1/2 phosphorylated extracellular signal-regulated kinase ½, TNF-α tumor necrosis factor-α, MMP2 matrix metalloproteinase-2, MMP9 matrix metalloproteinase-9, IL-17 interleukin-17, COX-2 cyclooxygenase-2, p-NF-κB phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cells, NS5A-Myc nonstructural protein 5A-Myc, AP-1 activator protein 1, 4-HNE 4-hydroxynonenal, 8-OHdG 8-hydroxy-2′-deoxyguanosine, GSH glutathione, HDLC high-density lipoprotein cholesterol, MDA malondialdehyde, LDLC low-density lipoprotein cholesterol, SOD superoxide dismutase, GR glutathione reductase, GPx glutathione peroxidase, ALP alkaline phosphatase