Table 1.
Common enzymatic mechanisms in MOF-NZs for therapeutic and diagnostic activities
| Function | Formulation | Application | Refs. |
|---|---|---|---|
| Oxidase | TPZ-GOx-ZIF-8@eM | Tumor therapy by Starvation/CHT in CT26 tumor xenografts model | [48] |
| Mem@GOx@ZIF-8@DOX | Tumor therapy by Starvation/CHT in 4T1 tumor xenografts model | [49] | |
| PCN@Pt@PCN-Au-FA | Tumor therapy by Starvation/PDT in 4T1 tumor xenografts model | [50] | |
| GOx@ZIF@MPN | Tumor therapy by Starvation/CDT in 4T1 tumor xenografts model | [51] | |
| Co‐Fc@GOx | Tumor therapy by Fenton reaction/CDT in 4T1 tumor xenografts model | [52] | |
| GOx-Hb@ZIF-8 | Tumor therapy by Fenton reaction/starvation therapy in MCF-7 and HeLa cancerous cells model | [53] | |
| AuNPs-Fe@GOx | Tumor therapy by PTT in microenvironment tumor model | [54] | |
| Peroxidase | DOX@MIL-100@HA | Tumor therapy by CDT/CHT in MCF-7 tumor xenografts model | [55] |
| IL@MIL-101(Fe)@ BSA-AuNCs | Tumor therapy by CDT/ PDT therapy in H22 liver tumor xenografts model | [56] | |
| DOX@PCN@-MnO2@PAH | Tumor therapy by glutathione-depletion /CHT/PDT in 4T1 tumor xenografts model | [57] | |
| BPQD/HKUST-1@MIL-100 (Fe)-GSNO | Tumor therapy by CDT/gas therapy/PTT in human gastric tumor xenografts model | [58] | |
| UsAuNPs/MOFs | Antibacterial therapy in antibacterial properties against both Gram‐negative and Gram‐positive bacteria model | [59] | |
| CAT | BQ-MIL@CAT-MIL | Tumor therapy by O2-evolving/PDT/PTT in human cervical cancer tumor xenografts model | [60] |
| mZIF-8@-CAT@DOX | Tumor therapy by O2-evolving/CHT/IMT in mouse melanoma tumor xenografts model | [61] | |
| BM@NCP(DSP)-PEG | Tumor therapy by O2-evolving/radiotherapy/IMT in 4T1 tumor xenografts model | [62] | |
| MOF-MBDHA@PLA@PEG | Tumor therapy by O2-evolving/PDT/CHT in mouse cervical tumor xenografts model | [63] | |
| MIL-100/GOx@HA-PDA | Tumor therapy by CDT/PTT/starvation in 4T1 tumor xenografts model | [64] | |
| SOD | PVP@CeNPs@MIL-100 | Alzheimer therapy by CDT in AD mouse model | [65] |
| Aptinib@PCN@MnO2@Tm | Tumor therapy by GSH-depletion/PDT/antiangiogenesis in 4T1 tumor xenografts model | [66] | |
| Pt@PCN222-Mn | Anti-inflammatory by CDT in IBD of mouse model | [67] | |
| Cu-TCPP-MOFs/nanodosts | Anti-inflammatory by hemodynamic therapy in an endotoxemia model in vivo | [68] | |
| PCN-224(Cu)GOx@MnO2 | Tumor therapy by GSH-depletion/CHT/anti-angiogenesis in U14 tumor xenografts model | [69] | |
| NH2- MIL-88B (Fe) | Tumor therapy by GSH-depletion/nano therapy in A375 and HeLa tumor xenografts model | [70] |