TABLE 1.

List of primary endpoints used in pivotal Alzheimer's disease trials, grouped by domain classification

Domain classification	Frequency
Cognitive only
Alzheimer's Disease Assessment Scale–Cognitive Subscale	145
Mini‐Mental State Examination	45
Severe Impairment Battery	24
Global Deterioration Scale	6
Neuropsychological Test Battery	3
Trail Making Test	3
Behavioral only
Neuropsychiatric Inventory	35
Cohen‐Mansfield Agitation Inventory	19
Brief Psychiatric Rating Scale	4
Geriatric Depression Scale	4
Behavioral Pathology in Alzheimer's Disease	3
Functional only
Alzheimer's Disease Cooperative Study–Activities of Daily Living	33
Activities of Daily Living	9
Disability Assessment for Dementia	9
Instrumental Activities of Daily Living	7
Physical Self‐Maintenance Scale	2
PROs only
Nighttime Total Sleep Time	4
Progressive Deterioration Scale	3
Caregiver Stress Scale	2
Quality of Life–Alzheimer's Disease	2
Biomarkers only
Magnetic Resonance Imaging	3
Positron Emission Tomography	2
Total Antioxidant Capacity	2
Multi‐domain
Clinician's Interview‐Based Impression of Change–Plus Caregiver Input	36
Clinical Dementia Rating Scale–Sum of Boxes	30
Clinical Global Impression of Change	21
Clinical Global Impression	16
Clinical Dementia Rating Scale	7

Note : For brevity, only the five most frequently used primary endpoints are shown for each domain grouping. A complete list of primary endpoints, including labeled cognitive/functional composite endpoints, is available in Appendix Table A2.