Figure 2.

Voxel-wise associations between higher total cerebral small vessel disease (SVD) scores and lower grey matter density were primarily found cortical and hippocampal areas, shown in blue. TFCE-corrected statistical maps are overlaid on the MNI-152 template and thresholded at a 1-p value of 0.95, representing p < 0.05. Images are also FWE-corrected for multiple voxel-wise comparisons. Analysis was adjusted for age, sex, education, MRI scanner model, antihypertensive use, body mass index, and mean arterial pressure measured at the time of the MRI scan.