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. 2021 Oct 5;42(4):600–612. doi: 10.1177/0271678X211048411

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© The Author(s) 2021

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Interaction between cognitive status and cerebral small vessel disease burden on global diffusion metrics. Plots depict significant interactions between cognitive status (Montreal Cognitive Assessment [MoCA]<26 vs. ≥26) and total SVD scores (0-3) on mean diffusivity, axial diffusivity, and radial diffusivity (all p<.05; depicted with *), but not for fractional anisotropy. The association between SVD burden and DTI parameters is more pronounced in individuals with cognitive impairments, reflected by MoCA < 26, and especially in the most severe SVD burden group.

MoCA: Montreal Cognitive Assessment; SVD: cerebral small vessel disease.