Table 2.
Longitudinal associations of vascular factors with SVD burden.
| MAP |
BMI |
Log-FSRS |
||||
|---|---|---|---|---|---|---|
| Beta | 95% CI | Beta | 95% CI | Beta | 95% CI | |
| Main effect of SVD burden group | ||||||
| SVD 1 vs. 0 | 1.75 | –0.18 to 3.67 | 0.04 | –0.63 to 0.70 | 0.06 | –0.002 to 0.11 |
| SVD 2 vs. 0 | 1.39 | –0.79 to 3.57 | 0.06 | –0.70 to 0.82 | 0.05 | –0.02 to 0.11 |
| SVD 3 vs. 0 | 3.36 | 0.42 to 6.30a | 0.13 | –0.89 to 1.15 | 0.05 | –0.03 to 0.14 |
| Interaction SVD group and time | ||||||
| Time×SVD 1 vs. 0 | –0.02 | –0.13 to 0.08 | 0.01 | –0.03 to 0.01 | 0.001 | –0.002 to 0.005 |
| Time×SVD 2 vs. 0 | –0.05 | –0.17 to 0.06 | 0.002 | –0.02 to 0.02 | 0.001 | –0.002 to 0.01 |
| Time×SVD 3 vs. 0 | –0.06 | –0.21 to 0.10 | –0.004 | –0.03 to 0.03 | 0.002 | –0.003 to 0.01 |
| Interaction SVD group and time2 | ||||||
| Time2×SVD 1 vs. 0 | –0.02 | –0.04 to 0.003 | ||||
| Time 2 ×SVD 2 vs. 0 | –0.01 | –0.04 to 0.01 | ||||
| Time 2 ×SVD 3 vs. 0 | 0.001 | –0.03 to 0.04 | ||||
Note: Results of linear mixed effect models with random effects for the intercept and slope (time for MAP, BMI FSRS and time2 for FSRS). Vascular risk factors were assessed between Wave 3 (1991–1994) and Wave 12 (2015–2016). All models were adjusted for age at baseline, sex, education, and scanner.
MAP: mean arterial pressure; BP: blood pressure; FSRS: Framingham Stroke Risk Score; CI: confidence interval; SVD: cerebral small vessel disease.
ap < 0.05.