Figure 1.

(a, b) Unmetabolized [¹⁸F]T-401 fraction in plasma over time in a baseline study of three rhesus monkeys (○M185, ●M187, ▲M197) (b) and in baseline and blockade studies of a rhesus monkey (M187) (b). Metabolic data at 120 min were unavailable in a blockade assay with 0.3 mg/kg of JW642. (c, d) Blood (orange dashed lines), plasma (sky-blue dashed lines) and plasma parent (solid sky-blue lines) radioactivity concentrations at baseline (c) and following pretreatment with 0.3 mg/kg of JW642 are plotted in logarithmic scale (d).