Figure 3.
(a) 2 T + mCM constructed as modification of 2TCM by adding a compartment (C3) for a radiometabolite converted from parent [18F]T-401 in the brain (c). K1, k2, k3, k4 and ktrans denote rate constants for the transfer of a radiocompound between different compartments. Red dotted rectangle represents the range of [18F]T-401 distribution in the brain. (b, c) Compartment model fits to cerebellum TACs at baseline (b) and following pretreatment with 0.3 mg/kg of JW642 (c). At baseline (b), 2TCM (green line) better described cerebellar TAC (black circles) than 1TCM (red line). Under blockade by JW642 (c), 2 T + mCM (solid sky-blue line) offered a better fit to cerebellar TAC (black circles) than 2TCM (green line).