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. Author manuscript; available in PMC: 2022 Jun 3.
Published in final edited form as: Mol Cell. 2021 Apr 13;81(11):2349–2360.e6. doi: 10.1016/j.molcel.2021.03.033

Figure 7. Dual regulation of hTERT mRNA as a function of pluripotency.

Figure 7.

Expression of hTERT mRNA is regulated by transcriptional and post-transcriptional processes. At the hTERT promoter, transcription initiation is governed by the recruitment of distal enhancer elements coupled with transcription factor binding. A second and critical regulatory step is exerted post-transcriptionally by alternative splicing of exon 2. SON, and possibly additional splicing co-factors, regulate the inclusion of hTERT exon 2 to produce a stable transcript that is translated into a functional telomerase reverse transcriptase.