KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit monoclonal Anti-SON	Novus Biologicals	NBP1-88706
Mouse monoclonal GAPDH (0411)	Santa Cruz Biotech.	sc-47724
Mouse monoclonal SSEA-4 (MC-813–70)	R&D Systems	MAB1435
Mouse monoclonal COL1A1 (3G3)	Santa Cruz Biotech.	sc-293182
Bacterial and virus strains
Cytotune iPS Sendai Reprogramming kit	ThermoFisher	A16517
One Shot Stbl3 Chemically Competent E. coli	ThermoFisher	C737303
Biological samples
Patient derived PBMCs	Dr. Savage, NIH	NCT-00027274
Chemicals, peptides, and recombinant proteins
Y-27632 2HCl	SelleckChem	S1049
Isoginkgetin	Tocris	6483
Critical commercial assays
Dual-Luciferase® Reporter Assay System	Promega	E1910
Nano-Glo® Dual-Luciferase® Reporter Assay System	Promega	N1610
DNA Prep Kit, Tagmentation	Illumina	20018704
Deposited data
Raw and analyzed sequencing data	This paper	GEO accession: GSE168193
Human reference genome NCBI build 37, GRCh37	Genome Reference Consortium	https://www.ncbi.nlm.nih.gov/projects/genome/assembly/grc/human/
Raw data at Mendeley	This paper	https://dx.doi.org/10.17632/jfmsvxnpbg.1
Experimental models: cell lines
Human: BJ Fibroblast	ATCC	CRL-2522
Human: ARPE-19	ATCC	CRL-2302
Human: HeLa	ATCC	CCL-2
Human: TREx-HeLa	Invitrogen	R71407
Human: H7 ESC	Dr. Lei Bu	WA07
Oligonucleotides
See Table S1	This paper	N/A
Recombinant DNA
pRF-HCV	Maria Barna	n/a
pNL1.1	Promega	N1001
pcDNA5/FRT/TO	ThermoFisher	V652020
Software and algorithms
4C-ker	Raviram et al., 2016	https://github.com/rr1859/R.4Cker
Oligostan	Tsanov et al., 2016	https://bitbucket.org/muellerflorian/fish_quant
ImageJ	Schneider et al., 2012	https://imagej.nih.gov/ij/
Bowtie2	Langmead and Salzberg, 2012	http://bowtie-bio.sourceforge.net/bowtie2/index.shtml
Samtools	Li et al., 2009	http://samtools.sourceforge.net/