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. Author manuscript; available in PMC: 2022 Mar 24.
Published in final edited form as: Steroids. 2021 Dec 27;178:108952. doi: 10.1016/j.steroids.2021.108952

Fig. 2.

Fig. 2.

(A) Rationally designed inhibitor for cytochrome P450 8B1. The incorporation of a pyridine ring at the C12-position should result in the coordination of the nitrogen lone pair from the inhibitor to the iron of the heme active site of cytochrome P450 8B1. (B) Structure of abiraterone for comparison.