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. Author manuscript; available in PMC: 2022 Sep 22.
Published in final edited form as: Chem Rev. 2020 Dec 23;121(18):10908–10949. doi: 10.1021/acs.chemrev.0c00923

Figure 10. Crosslinking via Schiff base formation.

Figure 10.

a) Schematic representation of imine dynamic covalent crosslinking by combining biopolymers modified with either primary amine or aldehyde groups. b) Schematic representation of hydrazone dynamic covalent crosslinking by combining biopolymers modified with either hydrazide or aldehyde groups. c) N-carboxyethyl chitosan (CEC) is combined with dialdehyde PEG (PEGDA, blue), where imine dynamic covalent crosslinks are formed between the amine groups on CEC and the aldehyde groups on PEGDA. Images show the self-healing (a-d) and shear-thinning (e-h) properties of the hydrogel. Adapted from Qu, et al.258 Copyright, 2017 Elsevier.