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. Author manuscript; available in PMC: 2022 Sep 22.
Published in final edited form as: Chem Rev. 2020 Dec 23;121(18):10908–10949. doi: 10.1021/acs.chemrev.0c00923

Figure 12. Crosslinking via reversible Diels-Alder reactions.

Figure 12.

a) Schematic representation of dynamic covalent crosslinks formed by combining biopolymers modified with either furan or maleimide groups. b) Hydroxypropyl chitin (HPC, black) modified with furan groups and combined with PEG-bismaleimide crosslinks for hydrogel formation. Immediately, a thermo-responsive physical hydrogel forms due to interactions between HPC molecules, and over time, reversible Diels-Alder crosslinks form to stabilize the hydrogel structure. Adapted from Bi, et al.296 Copyright, 2019 Elsevier.