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. Author manuscript; available in PMC: 2022 Sep 22.
Published in final edited form as: Chem Rev. 2020 Dec 23;121(18):10908–10949. doi: 10.1021/acs.chemrev.0c00923

Figure 4. Crosslinking via a thiol-ene radical addition.

Figure 4.

a) Schematic representation of norbornene-modified biopolymers (black) crosslinked with a dithiol crosslinker (pink) in the presence of a radical initiator. b) Thiol-norbornene crosslinked CMC hydrogels for bioprinting, showing (top) schematic representation of amidation reaction to synthesize norbornene-modified CMC (NorCMC), (middle) schematic representation of photocrosslinking reaction, and (bottom) bioprinted NorCMC scaffolds (clear) filled with Pluronic (red). Scale bars represent 5mm. Adapted with permission from Ji, et al.182 Copyright, 2020 Elsevier.